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Neuromodulation Although not universally classified as a classical neurotransmitter, glutathione can influence neural functions: It modulates the redox state of receptors such as the NMDA receptor, consistent with a neuromodulatory role

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Previous study reported that although Nrf2 deficiency may reduce trabecular bone mass, compensatory bone remodeling or individual differences could lead to higher trabecular bone in some KO mice 53 , which also highlighted the functional diversity of Nrf2

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes