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Retatrutide results from clinical trials show approximately 24.2% weight loss at 48 weeks, compared to roughly 16% with semaglutide (Ozempic/Wegovy) and 22.5% with tirzepatide (Mounjaro/Zepbound) at their respective maximum doses

The trial also reported secondary improvements in knee-pain scores, which matters for the eventual label scope but does not change the regulatory math for an obesity indication

Avoid exercising immediately after meals, though, as this can disrupt digestion

IOP Conf

Frequent diarrhoea may reduce the transit time through the small intestine, where iron absorption primarily occurs in the duodenum and proximal jejunum