semaglutide results 12 weeks Blog | Garland Sachse Wylie Murphy Medical clinic Understanding Semaglutide Dosing: Week-by-Week Guide

Insulin stimulated protein synthesis is mediated by activation of the protein kinases Akt and mTOR (specifically mTORC1 and mTORC2) in numerous insulin-responsive cell types, such as hepatocytes, adipocytes, and myocytes

GLP-1 is an incretin hormone produced by intestinal L-cells that stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and promotes satiety in response to food intake

These observations suggest that administration of metformin before meals may optimise its effect in improving postprandial glycaemic control

Key Takeaways GLP-1s and HRT work on different problems

A 2025 case series published in PMC demonstrated that supervised resistance training preserved lean soft tissue during GLP-1-induced weight loss