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While it has been studied over one to two years in clinical trials, there is limited data beyond that time frame, especially regarding: Long-term metabolic effects Nutrient deficiencies due to reduced food intake Potential changes to gut microbiota Dependency on the drug to maintain weight loss Potential changes to gut microbiota Some clinicians have voiced concern that stopping Ozempic can result in rapid weight regain and the return of previous metabolic issues

Dr Jovanovski said: "We are never going to really, truly address what's behind this issue if we only focus on new fads, because these are always going to change

The link between GLP-1 medications and true gastroparesis remains under investigation

This rebound phenomenon on cessation is somewhat discouraging and suggests that long-term effects may be expected

IV GSH is successful and expensive