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Treatment usually begins at 0.25 mg once weekly and is titrated upward over months, up to a maximum of 2.4 mg for weight management, which lets the body adjust and keeps side effects manageable

This damage is permanent and irreversible

www.fda.gov/news-events/press-announcements/ World Anti-Doping Agency

While effective, this approach carries risks including supraphysiological hormone levels, suppression of natural GH production, and side effects such as fluid retention, joint pain, carpal tunnel syndrome, and potential insulin resistance

Now, the question remains whether this observed benefit from incretin-based therapies also can be extended to PAD patients with or without T2DM