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Some studies have shown that GLP-1 medications can rapidly improve insulin sensitivity even before significant weight loss occurs, which indicates potentially independent mechanisms, like inflammation and oxidative stress reduction

Substitution with the non-native amino acid aminoisobutyric acid at position 2 confers resistance to DPP-IV degradation [17]

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In December 2025, Eli Lilly submitted the drug to the FDA for weight loss and plans to submit it for type 2 diabetes in 2026

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