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These effects are generally dose-dependent and tend to improve as the body adjusts to the medication

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For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%

Hypoglycaemia risk increases when Ozempic is combined with sulfonylureas or insulin, requiring dose adjustment of concomitant medications