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Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA

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Nevertheless, this latter in vivo study demonstrates that homocysteine ingestion in rat stimulates, in a dose-dependent manner, the transcription of aortic cyclin-dependent kinase, which is required for the mitosis and subsequent proliferation of vascular smooth muscle cells

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