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Researchers believe the cause is multifactorial due to inhibition of tyrosine and tryptophan hydroxylase, increased oxidative stress, altered lipid metabolism, and myelin sheath production.[ref] BH4 (as sapropterin) is used as a drug to treat phenylketonuria

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Injections: Corticosteroid injections may be recommended to reduce pain and inflammation in the joint

Research has explored its impact on the regulation of sleep cycles, particularly in promoting slow-wave (deep) sleep and improving stress adaptability through its interactions with the hypothalamic-pituitary axis

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