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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable
The commentary authors also pointed to growing debate around the use of anti-obesity drugs in children over age 12, warning that wider use could potentially increase the number of rare eye complications seen later in life
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2.9 Software and code: All design-based analyses were performed using R version 4.5.1 (2025-06-13 ucrt) and survey library version 4.4.8
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