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General eligibility criteria (based on FDA labelling and clinical trial protocols) include: BMI requirements: Adults with a BMI of 4045 kg/m or 3539.9 kg/m with at least one obesity-related comorbidity (such as type 2 diabetes, hypertension, or dyslipidaemia) Age: Typically between 18 and 65 years Previous weight loss attempts: Documented failure to achieve or maintain clinically significant weight loss through supervised diet, exercise, and behavioural modification programmes Psychological assessment: Patients must undergo psychological evaluation to ensure they have realistic expectations, can commit to long-term lifestyle changes, and can adhere to daily device charging requirements Absence of contraindications: No history of certain gastrointestinal conditions, previous gastric or oesophageal surgery, or conditions that would make laparoscopic surgery unsafe Specific contraindications (per device labelling) typically include: Cirrhosis or portal hypertension Significant hiatus hernia or gastro-oesophageal reflux disease requiring surgical intervention Previous gastric, oesophageal, or bariatric surgery Conditions requiring chronic anticoagulation that cannot be safely interrupted Pregnancy or plans to become pregnant (device should be switched off during pregnancy) Inability or unwillingness to comply with device charging and follow-up requirements In the UK, vagal nerve blockade is not routinely commissioned by the NHS

Initially, the rat was placed in the central chamber for a 5-minute habituation period

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It affects nearly every body system