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5.1 Intervention strategies 5.1.1 Targeting iron homeostasis Iron chelators such as deferoxamine, deferiprone, and deferasirox bind free ferrous iron (Fe2+), reducing substrate availability for the Fenton reaction and thereby curtailing the lipid peroxidation cascade (152)

This work was supported by the National Key Technology Support Program (2014BAD08B01) and the Agricultural Basic Research of the Shanghai Agriculture Commission (21, 2014), and the Developmental Plan of the Shanghai Agriculture Commission (142, 2015)

To identify key binding residues, we performed alanine-scanning mutagenesis across BPC157

However, it is essential to note that GSH levels in both dose groups generally returned to baseline levels after a one-month washout period, suggesting that continuous supplementation is necessary to maintain elevated GSH levels