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This should be done under the guidance of a healthcare provider, who can balance the dose adjustment with the need to maintain effective diabetes or obesity management

Avoid large food portions 1-2 days before your injection

Thyroid hormone replacement (levothyroxine) is often calculated based on body mass

Keep pen cap on when not in use Protect from excessive heat and sunlight SC Administration Administer SC to abdomen, thigh, or upper arm The time of day and the injection site can be changed without dose adjustment Administer once weekly, on the same day each week, at any time of day, with or without meals Visually inspect before use

Briefly, a 24-well culture plate was coated with 200 l (9.1 mg/ml)/well Matrigel prepared from Engelbreth-Holm-Swarm mouse tumors (Corning, MA, USA) and allowed to stand for 30 min at 37 C to form a gel layer