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Our criteria required that studies be randomised, enrol a sufficient sample size in the treatment arm (n 100), report substantial on-treatment weight loss ( 3 kg) and have at least two post-cessation data points or one data point after 12 weeks

In this study 35 (56%) patients exposed to GLP-1RAs had an increased incidence of RGC as compared to 12 (19%) of the non-users, a finding that persisted after adjustment for confounders

GLP-1 receptors are present in the brain, cerebral blood vessels, pancreas, heart, gastrointestinal tract, adipose tissue, kidney, and muscles, and consequently affect a variety of systems and processes [38,39,40]

Allergic reactions can range in severity and require immediate medical attention