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The N -terminal HisAla residues of GLP-1 are rapidly cleaved by DPP-4 expressed on surrounding tissues, resulting in the inactivation of GLP-1 ( Glucagon-like peptide-2 is a 33 amino-acid peptide and that is cleaved by DPP-4 in rodents and humans, but with a half-life that is slightly longer than GLP-1 ( via reducing bone reabsorption and improving bone mineral density (58)