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Semaglutide should be avoided by individuals with a history of thyroid cancer or MEN Type 2, or if there is a family history of these conditions

A 2014 Cochrane review found that when given within 48 hours of the onset of flu symptomssuch as fever, cough, sore throat, body aches, and chillsoseltamivir lessened the sick time for adults by about 17 hours and for children by 29 hours

This systemic suppression alters the bacterial balance in your intestines within 48 to 72 hours, often allowing opportunistic, pathogenic bacteria to overgrow, which results in osmotic diarrhea

Results depend on baseline weight, caloric deficit maintained, and adherence to medication schedule

Call 999 or go to A&E immediately if you experience: Severe chest pain or breathing difficulties Black, tarry stools or vomit that looks like coffee grounds with dizziness or weaknessthese are signs of significant gastrointestinal bleeding Facial swelling or severe allergic reactions affecting breathing Contact your GP urgently or call NHS 111 if: You experience severe or persistent abdominal pain , which could indicate gastric irritation or other complications You develop severe nausea or vomiting that prevents adequate fluid or food intake You experience signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst You notice swelling of ankles or legs , which could indicate fluid retention You develop unexplained breathlessness You experience allergic reactions such as rash or itching Before Starting Concurrent Treatment: Inform your prescriber about: All current medications, including over-the-counter products and supplements Any history of stomach ulcers, gastrointestinal bleeding, or kidney problems Previous adverse reactions to NSAIDs or GLP-1 medications Existing cardiovascular conditions Pregnancy, breastfeeding, or plans to conceive (semaglutide should be stopped at least 2 months before planned pregnancy