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have found that hematopoietic stem and progenitor cells are sensitive to the environment of young blood by constructing an allogeneic symbiosis model and mapping the single-cell transcriptome, as well as the fact that young blood can induce changes in hematopoietic and immune systems by restoring the levels of key transcription factors, such as activating transcription factor (Atf)3, Atf4 and C-C motif chemokine ligand (CCL3), which promotes the activation of stem cells and systematic rejuvenation of senescent tissues (100)

PMID 24368434

control FoB (Supplementary Fig

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Rutkove, S