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Preincubation of heart mitochondria of GSH-treated old animals with inhibitor CsA (10 5 mol/L) almost completely prevented Ca 2+ -induced mitochondrial swelling, which indicates the association of this process with mPTP opening (Figure 2A)

This also leads to numerous challenges in identifying which substances are currently permitted and which are prohibited in sports

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The necrotic nucleus extends outward into a region with low oxygen concentrations, referred to as hypoxia

doi: 10.1038/s41581-022-00601-z 70 SpinelliRBabootaRGoggSBeguinotFBlherMNerstedtAet al