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There is a regular feedback of errors from the DMC to the study sites

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If a recovery process is stalling, the question is always which bottleneck is still closed? rather than what else can be added? When Progress Stalls If the documented protocol appears to plateau in a research setting, the troubleshooting ladder below walks from the most likely mundane cause to the least

Unlike the points above, which each relate to ways of increasing the chance of finding effects, a final issue is about whether stimuli adequately or accurately capture the putative emotional odour