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While lifestyle interventions such as diet and exercise can normalize HbA1c, the benefits of GLP-1RA and SGLT2-i extend well beyond glycemic control and justify continuation of therapy
Importantly, insulin signaling has been demonstrated to be essential for post-inflammatory SP-D recovery (Fernndez-Real et al., 2010)
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"Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation." Nutrients
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