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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)
Pages 1009-1013
Several biomarkers deserve attention throughout the protocol
Effectiveness - Effectiveness for weight loss can vary based on treatment (see the How effective is Wegovy section below)
Sakurai R, Suzuki H, Ogawa S, Takahashi M, Fujiwara Y
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