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Peer review Peer review information Nature Communications thanks Seung-Jae Lee, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Although the direct inhibition of DPP-4 activity does not seem to regulate bone remodeling, the impact of DPP-4 on bone metabolism is indirect, involving the modulation of DPP-4 substrates and inflammation within the bone microenvironment
This is important because while a large number of immune cells in the gut are activated by GLP-1 very few immune cells containing GLP-1 receptors are present in other organs
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