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9,10 Summary A large body of high-quality evidence suggests that in patients with obesity without diabetes, GLP-1 and GIP/GLP-1 receptor agonists are associated with significant regain of lost weight after therapy discontinuation

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What persists is the downstream melanogenesis cascade: once MC1R is activated on melanocytes, those cells continue producing eumelanin through enzymatic pathways (tyrosinase, TYRP1, DCT) that don't require continuous peptide presence

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J Environ Chem Eng 7:103273 Pakdel M, Olsen A, Bar EMS (2023) A review of food contaminants and their pathways within food processing facilities using open food processing equipment