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Weight regain poses a major challenge to the long-term efficacy of GLP-1RAs after treatment cessation, which is particularly relevant as around half of patients discontinue treatment within the first year 8
What lifestyle changes need to happen
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If you experience hypoglycemia (low blood sugar levels), stop taking other glucose-lowering medications such as metformin and insulin glargine after consulting with your healthcare professional
Thyroid replacement (levothyroxine) absorption can be affected by GLP-1-induced slower gastric transit, so spacing doses 4+ hours apart from oral semaglutide or tirzepatide is recommended
