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They found that, indeed, there was a modest beneficial effect on kidney function even in people without kidney disease, and a larger beneficial effect in slowing rate of kidney function loss in people with kidney disease, explains Shuchi Anand, MD, MS, an associate professor of medicine (nephrology) at Stanford Medicine

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Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Moore, 1906), and in the 1960s a team of researchers in the UK and the US independently discovered the incretin effect, in which oral glucose markedly stimulates insulin secretion, setting the stage for the subsequent development of incretin (Elrick et al., 1964

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