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The yo-yo effect of weight loss followed by regain may be worse than maintaining a higher weight from the beginning. Dr Anoop Misra, chairman of the Fortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology in Delhi, noted that the findings may be particularly discouraging for people who are unable to exercise adequately due to conditions such as knee arthritis, and who struggle with appetite control

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The desensitization requires complex cycling protocols, and elevated cortisol promotes fat storage, working against weight loss goals

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