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These typically resolve without intervention and do not necessarily indicate hepatotoxicity
La vida media del pptido se sita en torno a los 6 das , lo que permite una administracin semanal, aunque la farmacocintica sugiere que estrategias de fraccionamiento de dosis o microdosing podran mantener niveles plasmticos ms estables (estado estacionario), minimizando los picos y valles que exacerban los efectos adversos gastrointestinales o taquicardizantes
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After a median follow-up of 7.9 years, the primary endpoint, 5-year disease-free survival, was 80.3% in the exercise group and 73.9% in the control group (difference, 6.4 percentage points
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