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The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Multiple studies have demonstrated that water fasting for up to 21 days is well-tolerated, but none focused on patients with severe obesity (body mass index 40) or utilized treatment with glucagon-like peptide-1 receptor agonists (GLP-1)
Acetyl L-Carnitine is a naturally occurring amino acid derivative involved in the normal transport of fatty acids within cells, where they are utilized as a source of energy
doi: 10.3390/v13040677 65 SabettaW.ParadisoA.PaciollaC.de PintoM
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