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The first reported observation that GTPases influence eryptosis was by Attanzio et al., who showed that NSC23766, a specific inhibitor of Rac1 GTPase, was able to ameliorate oxysterol-induced eryptosis [180]

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Without adequate glutathione stores, Phase 1 toxic intermediates accumulate in the liver and bloodstream, causing severe systemic inflammation and triggering hypersensitivity reactions commonly seen in patients with complex chronic illnesses