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J Biol Chem 276:29596602 Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, Bonetto V, Mengozzi M, Duffieux F, Miclet E, Bachi A, Vanekerckhove J, Gianazza E, Ghezzi P (2002) Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
The Phase 2 double-blind, placebo-controlled RCT (NCT03018054) tested 30mg and 60mg doses versus placebo once daily for 8 weeks in 147 Japanese participants aged 2074 with moderate active UC (MS 6-10, MES 2, RBS 1) who had inadequate response to standard treatments
Semaglutide provides a lower-risk, hormone-based approach, with the best choice depending on individual BMI, health goals, and risk tolerance
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Despite this evidence, a critical gap remains
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