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& Smith, S.R

When discontinued, appetite returns typically to or near pre-treatment levels and most patients regain a significant proportion of lost weight over 1218 months without the medication

Exendin-4 administration did not modify S6K activity in the LH of lean and obese rats after four hours of re-feeding, whereas exendin-4 reduced S6K activity in the VMH of lean Zucker rats but not in their obese counterparts [83]

These reports are uncommon and often involve patients with pre-existing liver conditions, concurrent medications, or other confounding factors