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10.1369/0022155415583535 13 BuseJ
Why Hypothyroidism Patients May Require Levothyroxine Adjustments Hypothyroidism slows metabolism, and levothyroxine dosing is calibrated based on body weight and metabolic needs
disposition model, which were effects of body weight on clearance (CL), inter-compartment CL ( Q ), central volume ( V c ) and peripheral volume ( V p ), and effect of glycaemic status on CL
This requires comprehensive comparability studies against the reference listed drug (RLD), encompassing physicochemical, structural, and biological attributes
Data collection will run on a DNBSEQ-G400RS sequencer with DNBSEQ-G400RS High-throughput Sequencing Set (FCL PE150) (both MGI Tech Co., Shenzen, China)
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