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SOD is the primary enzyme of Asada-Halliwell pathway that causes dismutation of superoxide radicals under elevated levels of H2O2 followed by further hydrolysis into H2O and O2 by CAT and APOX or other POD enzymes present in various cellular organelles (Keramat et al., 2010
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The Itga8-Cre/Itga8-CreERT2 model avoids myeloid cell leakage and does not induce the lethal visceral myopathy commonly seen in Myh11-driven models, making it an ideal tool for studying VSMC sex differences and remodeling processes [238, 239]
In addition, other second messenger pathways, including cAMP and G-protein pathways, are influenced by Li (Agranoff and Fisher, 2001
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