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As Deb Burgard pointed out, in SA Figure S5, the hazard ratios are not significant for women, Black people, Hispanic people, people over 75, and - big one - fatter people. So, lets re-write their opening paragraph to be..whats the wordoh, yeah: Accurate

Consider staying at your current dose for an additional 2-4 weeks if you experience: Persistent nausea or vomiting lasting more than 3 days Rapid weight loss exceeding 3-4 lbs per week Severe constipation or diarrhea Signs of dehydration Significant injection site reactions The goal is to reach the maintenance dose gradually

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This means patients can access straight tirzepatide at a discounted rate while supplies last

Stellate ganglion block studies will be difficult to fully mask, because participants who get the anesthetic will have Horner syndrome, a very visible but temporary condition that affects a persons facial appearance