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We always want nutrition and lifestyle to be our foundation and sometimes we need a drug
In markets where there is state/PMI reimbursement of GLP-1 treatment for obesity (eg the US), retatrutide is likely to be reserved as a second-line GLP-1 for those who have failed to lose sufficient weight with a cheaper alternative (such as semaglutide or tirzepatide)
In 2021, semaglutide 2.4 mg became the most-effective GLP-1 RA approved for obesity management with 14.9% mean WL at 68 weeks vs
In three studies, supplementations were combined with carbohydrates (CHO) [5,6,7], and in one with L-leucine [18]
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