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These findings suggest that ACSF2 may alleviate inflammatory responses in IBD and delay the progression of experimental colitis by inhibiting ferroptosis pathways

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Autophagy regulation is extremely complicated and involves multiple stimulatory or inhibitory factors or signal pathways, such as PI3KI-protein kinase B (AKT)-mammalian target of rapamycin complex 1 (mTORC1), adenosine monophosphate-dependent protein kinase (AMPK)-mTORC1 pathway, B cell lymphoma 2 (Bcl2)-Beclin1 pathway and p53