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Increased levels of ROS and lipid peroxidation products and/or decreased levels of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, and antioxidant compounds, such as glutathione, have been reported in both NAFLD/NASH patients as well as a variety of animal models of NAFLD 9,10,11,12,13,14
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However, excessive force causes unnecessary tissue damage
BSO treatment alone did not significantly decrease cell viability (data not shown) and had no profound effect on the cytotoxicity of AQ or DEAQ ( Figure 2 )