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This review will first highlight the pathophysiological mechanisms underlying the onset and progression of ADRD

doi: 10.1152/ajpcell.00375.2021 3 TaquetMDerconQLucianoSGeddesJRHusainMHarrisonPJ

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Following ER stress or chemotherapy, an LTC4 biosynthetic machinery, consisting of microsomal glutathione-S-transferase 2 (MGST2), 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and cytoplasmic phospholipase A2 (cPLA2), was activated by assembly at the nuclear envelope

This distinction is fundamental to understanding its regulatory status and how it is perceived in both scientific and public domains