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The pivotal role of the gut microbiota is underscored by evidence demonstrating that the protective effects of a steamed broccoli sprout diet against colitis are entirely dependent on its presence, as it generates bioactive sulforaphane in the colon even when the plants own myrosinase is inactivated (51)

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FOXO4 is a member of the broader FOXO protein family, which has preserved both structural and functional characteristics across various animal species and has long been associated with pathways influencing aging

Activation of muscarinic cholinergic receptors inhibits giant neurones in the caudal pontine reticular nucleus

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