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Linge, J., Birkenfeld, A
The mechanism likely involves rapid shifts in metabolic rate and fluid balance as GLP-1 receptors activate throughout your nervous and digestive systems
Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs ( In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (42)
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Katherine Tuttle, professor of medicine at the University of Washington School of Medicine and executive director for Research Providence Inland Northwest Health in Spokane, Washington, emphasized that people with type 1 diabetes have an especially high risk of chronic kidney disease (CKD)
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