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Traditionally, they have been studied in isolation, but a burgeoning body of evidence now positions them as manifestations of a shared systemic age-associated metabolic dysfunction ( 2 Sarcopenia and metabolic mechanism Sarcopenia is a multifactorial syndrome driven by a complex interplay of metabolic dysregulations that create a self-perpetuating cycle of muscle wasting ( This metabolic dysfunction is exacerbated by inflammaging, characterized by elevated pro-inflammatory cytokines such as TNF-, IL-6, and C-reactive protein (CRP) ( Mitochondrial dysfunction is another key pillar of sarcopenia

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Despite clinical evidence supporting low-dose testosterone for hypoactive sexual desire and other symptoms in perimenopausal and postmenopausal women, there is no FDA-approved testosterone product for women in the United States