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Chantalat, E., Valera, C., Vaysse, C., Noirrit, E., Rusidze, M., Weyl, A., Vergriete, K., Buscail, E., Lluel, P., Fontaine, C., Arnal, F., & Lenfant, F

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Starting berberine at lower doses (500 mg daily) before escalating, or using it strategically after GLP-1 tolerance stabilizes, helps minimize overlapping adverse effects

It has been shown that exendin-4 reduces mitochondrial toxicity in an A-induced AD mouse model, an effect that was mediated through PI3K/protein kinase B (Akt) signaling [53]