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Research demonstrates that acetyl-L-carnitine ameliorates insulin resistance through multiple mechanisms: restoring tissue carnitine levels in skeletal muscle and myocardium, improving mitochondrial -oxidation of fatty acids to reduce accumulation of lipotoxic intermediates, enhancing glucose disposal and oxidation capacity, and reducing inflammatory signaling that impairs insulin receptor function
doi: 10.1146/annurev-biochem-062917-011852 27
& Strange, R
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