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most other claimed benefits (bone density, body composition) trace back to animal studies or preliminary/anecdotal reports, not confirmed human efficacy trials

Linkermann, A

In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

Studied in controlled in vitro systems for insulinotropic activity on pancreatic beta-cell lines

Rare (may affect up to 1 in 1000 people): Hip fractures