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Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths

In the STEP 1 trial of the Wegovy injection, nausea affected around 44% of people, diarrhoea around 30%, and vomiting around 25%

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Additionally, before and after each medication the thoracic fluid index was measured with bioimpedance cardiography (Physioflow Enduro, Manatec Biomedical, France) and blood samples were collected for the measurement of plasma bioactive renin, aldosterone and atrial natriuretic peptide (ANP)

When levels are low, these metabolites can recirculate, contributing to symptoms of oestrogen excess