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Medical oversight A key point regarding GLP-1 medications, including in a microdosing context, is that they are prescription drugs designed for specific medical conditions (like type 2 diabetes and obesity) and require professional guidance

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Contrary to this, intraperitoneal administration of GLP-1 agonists does not stimulate vagal afferents 33 , only a small subset of GLP-1R-expressing vagal afferents innervate the intestinal mucosa where GLP-1 cells reside 33,34 , and ablation of vagal GLP-1R neurons doesnt prevent GLP-1Rs satiating effects 35