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Stress, Cortisol, and Oxidative Burden Chronic psychological stress elevates cortisol and other stress hormones, which increase oxidative stress through multiple mechanisms including promotion of inflammatory cytokine production, impairment of antioxidant enzyme function, increased metabolic rate and oxygen consumption, and disruption of sleep and other restorative processes
For example, endocrine disruptors such as insecticides, flame retardants, and phthalates from plastics, are specifically toxic to the male hormones responsible for sperm production
These studies collectively contribute new insights into understanding the role of oxidative stress in IBD and potential therapeutic avenues targeting ROS-mediated pathways in the management of this condition
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