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Abdominal obesity In a 12-month clinical trial published in 2010, which involved 404 HIV-infected patients with excess abdominal fat, the group that received 2mg of tesamorelin per day saw an 18% decrease in visceral fat compared to placebo.9 There are two things to note in order to appreciate the full scope of these findings: Visceral fat (i.e., fat accumulation around the abdominal organs) is famously stubborn and cant be burned selectively through exercise
Li S, Wei X, He J, Tian X, Yuan S, Sun L
Furthermore, subchondral angiogenesis, often driven by VEGF and mechanical stress, disrupts the osteochondral interface and promotes cartilage deterioration (Noh et al., 2020)
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