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When functionally activated, UCP1 permits proton conductance that reduces coupling between substrate oxidation and ATP production
These include midodrine, an alpha-1 adrenergic agonist approved by the FDA for symptomatic orthostatic hypotension that induces vasoconstriction to increase peripheral resistance and standing blood pressure
[PMID: 3768030] PubMed record related to this compound for laboratory literature review
In particular, nitric oxide (NO) regulates vascular tone and blood flow by promoting the relaxation of all types of blood vessels, including arteries a phenomenon called vasodilation
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