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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

The authors acknowledge that the Figures 2 , 4 , 5 were generated using SCI Mechanism Diagram Generator for visual representation of data

Medicine & Science in Sports & Exercise